Foldry.bio turns your sequence and assay constraints into a lab-ready Enzyme Design Pack — ranked mutations, compact libraries, risk flags, and handoff files. In 10 days. No tool setup. No wasted plates.
Sound familiar?
The Enzyme Design Pack
You provide one sequence and your constraints. We deliver a complete, ready-to-run pack in 10 days.
Ensemble-scored variants (sequence LM + structural heuristics + your do-not-mutate constraints), sorted by predicted hit probability.
High-confidence, diverse picks optimized for your tight library budget — ready to order.
Broader coverage including long-shot bets, staged so you can run both plates from the same sprint.
Expressibility concerns, stability trade-offs, and epistasis warnings surfaced before you go to bench.
CSV/FASTA/JSON ready for your synthesis vendor and LIMS. Zero reformatting.
Send back your assay data and get an updated prioritization before your next build.
How it works
One FASTA, your target property, assay conditions, library budget, and any locked positions. A 30-min intake call if needed.
Fast ensemble: language-model embeddings, structural heuristics, constraint filtering. Top-K candidates get AlphaFold2 checks.
Ranked list, two libraries, risk report, handoff files — everything the wet lab needs to order and run the next round.
Feed back hits/misses. We update priors and prepare round 2, making each DBTL cycle smarter than the last.
Why it works
Typical hit enrichment vs random mutagenesis on public thermostability benchmarks (enrichment@96).
Fixed scope, fixed timeline. You know exactly what you'll receive and when — no open-ended consulting.
No tool installation, no pipeline management. Just a sequence in, a library out, and your wet lab running the next round.
Note
We don't guarantee improvement in a single round — no honest service does. What we guarantee is a hit-enriched library that beats random, interpretable rationale for every candidate, and a learning loop that compounds across rounds.
Pricing
Discovery
Free
30-min scoping call
Design Pack
$3,500
per sprint · 10 days
Retainer
Custom
ongoing DBTL partnership
Get started
Send us a quick note — what enzyme, what property, what timeline. We'll reply within 24 hours to confirm fit and book a scoping call.
Email hello@foldry.bio→NDA available before any technical discussion.